Cardioprotective activity of standardized extract ofFicus racemosastem bark against doxorubicin-induced toxicity
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چکیده
منابع مشابه
Scientific validation of cardioprotective attribute by standardized extract of Bombyx mori against doxorubicin-induced cardiotoxicity in murine model
Doxorubicin (DOX) is an excellent antineoplastic agent used for the treatment of hematological and solid malignancies. The aqueous extract of Bombyx mori (BMAE) contains amino acids and some flavonoids with obvious cardioprotective effect. The aim of this study was to investigate the possible protective effect of BMAE against DOX-induced cardiotoxicity and its underlying mechanisms on murine mo...
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Purpose: The aim of the present study was to determine the ability of grape seed extract (GSE) as a powerful antioxidant in preventing adverse effect of doxorubicin (DOX) on heart function. Methods: Male rats were divided into three groups: control, DOX (2 mg/kg/48h, for 12 days) and GSE (100 mg/kg/24h, for 16 days) plus DOX. Left ventricular (LV) function and hemodynamic parameters were assess...
متن کاملEvaluation of the potential cardioprotective activity of some Saudi plants against doxorubicin toxicity.
Doxorubicin (DOX) is an anthracycline antibiotic widely used as a chemotherapeutic agent in the treatment of several tumours. However, its cardiac toxicity limits its use at maximum therapeutic doses. Most studies implicated increased oxidative stress as the major determinant of DOX cardiotoxicity. The local Saudi flora is very rich in a variety of plants of quite known folkloric or traditional...
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Preventive role of lipistat against doxorubicin induced myocardial toxicity in rats has been reported. Cardiotoxicity was produced by doxorubicin administration (15 mg/kg for 2 weeks). Lipistat (350 mg/kg, orally) was administered as pretreatment for 2 weeks and then for 2 weeks alternated with doxorubicin. The general observations, mortality, histopathology, biomarker enzymes like lactate dehy...
متن کاملCardioprotective Activity of Fruit Extracts of Momordica Dioca Roxb. on Doxorubicin Induced Toxicity on Rats
Background: Cardiovascular diseases are the major death causing disease worldwide and identification of herb based therapeutics is the need of today. Present study was undertaken to evaluate the cardioprotective activity of Momordica dioca Roxb. (MDR) fruit extract on doxorubicin (DXR) induced cardiotoxicity on rats. Methods: The crude methanolic extract (MEMD) was prepared by soxhlet extractio...
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ژورنال
عنوان ژورنال: Pharmaceutical Biology
سال: 2011
ISSN: 1388-0209,1744-5116
DOI: 10.3109/13880209.2011.613848